PSYCH 477 Lecture Notes - Lecture 10: Preterm Birth, Temporal Lobe, Macguffin
Document Summary
Mz twins of probands: 70 90% concordance for asd. Genetic (cid:498)parentability(cid:499) (cid:498)broader autism phenotype(cid:499): family members show minor doesn"t infer to clinically relvant impairment, difference in personality that go along of multiple genes and we don"t yet have technology to study interaction of. Still cannot paint a clear picture of the cause(s) of autism large proportion of variance in asd. No single area of the area, multiple and pervasive. Abnormal brain growth, btw ages of 1. 5 to 5 yrs. Evidence of cerebral gray and white mater overgrowth clearly evident by age 2. 5 (but we do not know what causes the abnormal growth) Cellular abnormalities in many parts of brain: structural and functional abnormalities in cerebellum, medial temporal lobe, and associated limbic structures. We can observe the neural connectivity over time between areas involved in social understanding. Gotts et al. (2012): < connectivity in areas of brain involved in social function nimh.
