BIOCHEM 420 Lecture Notes - Lecture 19: Acetyl-Coa, Beta Oxidation, Alpha And Beta Carbon

• School: UMASS-Amherst
• Department: Biochemistry & Molecular Bio.
• Course: BIOCHEM 420
• Professor: Becky Miller

Document Summary

16. 2: describe the physiological circumstances that will lead to ketogenesis. (sec. 16. 2: draw a cell and indicate where each part of fatty acid oxidation and fatty acid synthesis occur. (sec. 16. 3: summarize the 3 main ways acetyl-coa can be used in cells. (sec. Fatty acids need to be activated in the cytoplasm and transported to the mitochondria. The enzymes of fatty acid oxidation are in the mitochondrial matrix. Fatty acids are oxidized in a step wise fashion, with the initial attack on carbon 3 (beta carbon: this releases 2 carbons & the remainder of the fatty acid molecule could undergo another oxidation. Fatty acids are activated for oxidation by atp-dependent acylation of coenzyme a. Fatty acid oxidation begins in the cytoplasm, but most reactions occur in the mitochondria. This transport is carried out by carnitine acyltransferase system. Once inside, acyl-coa cannot be transported out (one-way system) Inner mitochondrial membrane is impermeable to bulky polar molecules like coa.