BIOLOGY 283 Lecture Notes - Lecture 21: Dystrophin, Myocyte, Shock Absorber
4 Dec 2018
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Lecture 21 on outline transcription factors a- ones across species. , necessity and molecular function : muscular dystrophy causative gene is known dystrophin l dub ) Dmd is x - linked what is muscular dystrophy cmd ) Be this leads to chronic muscle damage , inflammation and eventually replacement of muscle fiber fat and fibrotic tissue . by on most md patients will develop cardiomypathy - Muscle that makes it hard a serious problem with for the heart and send blood to pump it to the. Gene body . large gene that can have many different mutations that lead to muscular dystrophy . The mutation rate for dystrophin is relatively high , in one in three cases. Dmd is caused by a de novo mutation . mutation brand new an splicing on short sequences in the primary transcript dictate where splicing occurs. Lona the intron is gone , it gets degraded . : splicing happens in nucleus.
