MICROBIO 160 Lecture Notes - Lecture 26: Treatment As Prevention, Drug Resistance, Rash

• School: UMASS-Amherst
• Department: Microbiology
• Course: MICROBIO 160
• Professor: Mitchell Walkowicz

Document Summary

Biology of cancer and aids 12/2/15: treating hiv/aids. Interventions against hiv (as hiv progresses: need a doctor, general health maintenance (no excess drinking, no smoking, healthy diet, supportive therapies, anti-hiv treatment strategy. When to start antiretroviral therapy: hiv + pregnant women start faster, hiv + tb coinfection start faster. Reduce hiv levels (viral load) below limit of detection (<50 copies hiv rna) Increase t-cell count: minimize drug toxicity, manage side effects and drug interactions. Consider hiv viral load, cd4+ cell counts, general health status (symptoms of hiv disease or recurrent health conditions despite treatment) Hiv and current drug targets: give infected cell fake nucleotide so that replication cannot continue. Inhibit integrase which incorporates viral dna into host chromosome. Protease inhibitor bind to protease, buds off original infected cell but protease is inactivated so it is not an infectious cell. Reverse transcriptase (rt) inhibitors interfere with critical step during hiv life cycle known as reverse transcriptase.