MICROBIO 160 Lecture Notes - Lecture 22: Macrophage, Syncytium, T Helper Cell
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MICROBIO 160 Full Course Notes
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Biology of cancer and aids 11/16/15: biology of hiv. What does hiv look like: an hiv particle is around 100-150 billionths if a meter in diameter (about the same are 4 millionths of an inch, major components. The double-stranded dna is incorporated as a provirus into the cell"s dna. Proviral genes are transcribed into rna molecules which serve as genomes for the next viral generation and as mrnas for translation into viral proteins. Viral proteins include capsid proteins and reverse transcriptase (made in cytosol) and envelope glycoproteins (made in er) Vesicles transport the glycoproteins from the er to the cell"s plasma membrane. Capsids are assembled around viral genomes and reverse transcriptase molecules: new viruses bud off from the host cell. Binding of hiv to cd4 t-cell: hiv binding via cell surface receptors. Cxcr4-tropic virus emerges in 50-60% of infected individuals within 5 years. R4-tropic (t-tropic virus) associated with pronounced depletion of cd4 t cells.