PSYCH 330 Lecture Notes - Lecture 10: Autoreceptor, Suppository, Intramuscular Injection
22 Oct 2018
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Routes of administration-speed of effects as you go down the list. Drugs can affect any of the steps of synaptic transmission to achieve effects. 1: destroy synthesizing enzymes (inhibit, prevent storage of nt in vesicles (inhibit, decrease nt release (inhibit, stimulate release of nt (enhance, activate autoreceptor (inhibit) [agonist, block autoreceptor (enhance) [antagonist] Postsynaptic: stimulate postsynaptic receptors (enhance) [agonist, block postsynaptic receptors (inhibit) [antagonist] While nts activate entire classes of receptors, drugs often show more specificity to a single type of receptor. Benzodiazepines used to treat anxiety only bind to gabaa receptors and not gabab receptors. Binding affinity: the degree of chemical attraction between a ligand and a receptor. Lower: need to use more dosage in order to get the same effect. Efficacy: the ability of a bound ligand to activate receptor. Anti-anxiety drug buspar is a partial for post-synaptic 5-ht1a receptors. Effects: stimulates release of glucose;increase heart rate, blood pressure, feelings of relaxation, calm, sharpness, and alertness.
