CHEM 2301 Lecture Notes - Lecture 18: Activation Energy, Moodle, Substitution Reaction
Document Summary
Chem-2301 lecture 18 notes-chapter 5. 11 stereochemistry and sn-1 mechanisms. Trigonal planar intermediate means the nucleophile has 2 possible routes of attack. It can either attack from the top face, or the bottom face. When looking at secondary and tertiary options, in terms of carbocation stability, having to options of attack does not mean that both are equally favored. If you look at the mechanism, you have to have a water molecule leak. In order to generate carbocationone, the has to be a water leak. When reacting alcohol with a hydrogen halide. first step- proton transfer. Reminder- it"s a slow step in order to get the water molecule to diffuse away. Show that water molecule left but no longer bonded. Takes time of water molecules to diffuse away. Hence more products from when the chloride is attaching. What happens to the configuration when there"s a chirality center.
