CHEM 2332H Lecture Notes - Nucleophile, Benzaldehyde
15 Jul 2014
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Another thing to think about besides # steps = amt yield. Yield monster suppose we have red percentages of yield. 0. 9*0. 9*0. 9*0. 9 = 0. 6561 or do avg yield = [avg per step yield]n = 0. 66. The more steps you add, the lower your product of decimals will be. Also consider the formation of byproducts, isomers, losses in each step. If use less stuff, then better for environment, less stuff to have to dispose properlyless stuff to buy in the first place. Case 1: strong acid + weak nucleophile use the strong reagent (acid) first, then weak reagent later when you protonate, you make stronger nucleophile that can then react more like sn1 than sn2. Use cyanohydrin: secondary centers aren"t as good so kcn = good for this. Ochem page 2 weak acid first protonate second protonate second weak acid first. ->if all different groups, then you will form both stereoisomers (same case for the case 1)
