CHEM 2332H Lecture Notes - Electrophile, Opata Language
15 Jul 2014
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Hydrolysis of nitriles * can stop @ primary amide if don"t keep it going too long (more time or more heat) This is used more b/c sodium formate is really cheap saltif not, then start with carboxylic acid. Rare cases, can take diacids (2 acids) and heat them a lot. Ochem page 1 so hot that just boil off water as steam. Why bother with anhydride if same case w/ acid chlorides?could be very cheap starting materials for large scale phthalic anhydride succinic anhydride acetic anhydride maleic anhydride can undergo diels alder rxn. Most of these all = ring, so don"t need to worry about having 2 equiv (don"t have to worry about previous rxns)can just close ring and it already has the 2 equiv. Remember, when in ring, carboxylate"s still attached to your end compound since it"s just 1 thing. In friedel crafts rxn not as leaving group as the chloride might happen, but not as likely.
