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HMED 3075 (18)
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Lecture 18

HMED 3075 Lecture 18: Pharmacogenomic Innovations
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Department
History of Medicine
Course Code
HMED 3075
Professor
Tobbell D

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HMED 3075 Lecture Notes on 11/28/16 Market Race
o Lecture: Pharmacogenomic Innovations
o Reading:
Deborah Bolnick et al., “The Science and Business of Genetic Ancestry
Testing.” Science (Oct. 19, 2007) 318: 399-400.
Alondra Nelson, “Bio Science: Genealogy Testing and the Pursuit of African Ancestry”
Pharmacogenomics as Genomic Innovation:
Pharmacogenetics: the study of how gees affet a perso’s respose to drugs
Pharmacogenomics: screening the genome for pharmacogenetic reactions
Physicians understand that people have different reactions to the treatments they
receive
Pharmacogenomics and Personalized Medicine:
Pharmaceutical companies became intensely interested in pharmacogenomics drug
development in the late 1990s
Companies instead develop drugs targeted to these specific genetic variants
o Removes uncertainty from the drug development process
o Reduces potential for adverse drug reactions
o Reduces drug development costs by shortening length of trials and thus time to
FDA approval
o Will reduce health care expenditures on prescription drugs
Accessing Pharmacogenomic Information:
Information available on the FDA website and from the drug label
Companies like GeneSight offers pharmacogenetics testing that help determine drugs to
prescribe
Herceptin: A Pharmacogenomic Drug
Poster drug for personalized medicine
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Description
HMED 3075 Lecture Notes on 11/28/16 Market Race o Lecture: Pharmacogenomic Innovations o Reading:  Deborah Bolnick et al., “The Science and Business of Genetic Ancestry Testing.” Science (Oct. 19, 2007) 318: 399-400.  Alondra Nelson, “Bio Science: Genealogy Testing and the Pursuit of African Ancestry” Pharmacogenomics as Genomic Innovation:  Pharmacogenetics: the study of how genes affect a person’s response to drugs  Pharmacogenomics: screening the genome for pharmacogenetic reactions  Physicians understand that people have different reactions to the treatments they receive Pharmacogenomics and Personalized Medicine:  Pharmaceutical companies became intensely interested in pharmacogenomics drug development in the late 1990s  Companies instead develop drugs targeted to these specific genetic variants o Removes uncertainty from the drug development process o Reduces potential for adverse drug reactions o Reduces drug development costs by shortening length of trials and thus
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