PSY 3061 Lecture Notes - Lecture 18: Anterograde Amnesia, Retrograde Amnesia, Autobiographical Memory
Document Summary
Nmda coincidence detector: depolarization event from presynaptic neuron, glutamate released, depolarization of postsynaptic neuron, mg+ block pushed out, active receptor. Implicit: used a lot more often than explicit memory, easier: priming: neocortex, procedural (skills, habits): striatum, emotional: amygdala, motor learning: cerebellum, nonassociative learning (e. g. , habituation): reflex pathways. Retrograde amnesia and anterograde amnesia: retrograde amnesia: cannot remember events prior to brain damage, anterograde amnesia: cannot later remember events that occur after brain damage. Incomplete-pictures test: but deficits on others, digit span + 1 test, block-tapping memory-span test. Ltp at glutamatergic synapses in hippocampus: schaffer collaterals (critical for signal transduction and long-term potentiation in hippocampus) ca1 pyramidal cell dendrites, mossy fibers (granule cells) pyramidal cell dendrites, perforant path granule cells dendrites (dg) Amnesia: the case of r. b: heart surgery. Ischemia brain damage: amnesia similar, but less severe than h. m, post mortem: damage restricted to pyramidal cell layer of ca1 hippocampal subfield, further cases reported more recently where damage restricted to hippocampus alone.
