BIOS 111 Lecture Notes - Lecture 34: Hmg-Coa Reductase, Candida Glabrata, Amphotericin B
Document Summary
There is a shortage in antifungal antibiotics. 30-40% mortality rate due to shortage of good antifungal antibiotics. Mode of action is to sink into cytoplasmic membrane of fungus. Target in cytoplasmic membrane of amphotericin b. Antifungal antibiotics and antibacterial antibiotics have different structures and different modes of action. Until it was found aids was viral, victims could donate blood. Candida albicans cause 50% of aids death. They were treated with amphotericin b and would die. The fungus got resistant to amphotericin b. Diflucan can be taken orally or intravenously. Diflucan is taken for vaginal yeast infections. 70% chance of severe fungal infections in transplant patients because of immunosuppressant drugs. Immunosuppressants are necessary for the body to accept the transplant but they don"t let your body fight off fungal infections. ~85% of yeast infections are caused by candida albicans. 15% of yeast infections are caused by candida glabrata. Voriconazole or posaconazole is used for c. glabrata.
