BIOS 111 Lecture Notes - Lecture 7: Umbilical Cord, Tetanospasmin, Tetanus

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8 Feb 2017
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Disease of the Day - Tetanus (1/25/17)
Tetanus = lockjaw
People would get spores of tetanospasmin by bullet wounds.
The muscles contract, causing the victim to die from exhaustion
The muscles fight against each other
It’s a type of paralysis where all muscles are contracted
Clostridium tetani is Gram-positive, rod-shaped, anaerobic, and spore-forming.
It doesn’t spread person-to-person, but by wounds.
Wounds
Stepping on a nail
Abortion
Circumcision
Umbilical cord being cut
Bullet wound
Pierced ears
Dirty needles
Wound itself might be trivial
Any place with large numbers of horses is flooded with tetanus
It’s common in dirt, soil, and manure.
Tetanus bacterial spores get in through wounds, get into the bloodstream, and then
get delivered to the brain. When reaching the brain, it infects the neurons.
Clostridium tetani produces neurotoxin because it targets nerves.
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