I need help with the following, I am having trouble finding the answers in the video lecture given to us. Thanks!
1. Tetrodotoxin acts by: A) Blocking potassium channels B) Blocking sodium channels C) Preventing acetylcholine release at the nerve terminal D) Preventing serotonin reuptake
2. Ecstasy has the dual action of increasing release and blocking reuptake of: A) Serotonin B) Dopamine C) Norepinephrine D) All of the above
3. MPTP is metabolized into MPP+ by: A) Astrocytes B) Oligodendrocytes C) Dopaminergic neurons D) Myelin
4. Organophosphate pesticides act by: A) Increasing release of acetylcholine B) Preventing reuptake of acetylcholine C) Mimicking acetylcholine D) Inhibiting acetylcholinesterase
5. Botulinum toxin acts by: A) Blocking release of acetylcholine B) Preventing reuptake of acetylcholine C) Mimicking acetylcholine D) Inhibiting acetylcholinesterase 6. Compounds that cross the blood-brain barrier tend to be: A) Lipophilic B) Non-polar C) Low molecular weight D) All of the above
7. Acetaminophen is metabolized by the following Phase I enzyme: A) Glucuronyl transferase B) CYP2E1 C) CYP3A4 D) None of the above
8. The increased hepatic expression of CYP450 is called: A) Inhibition B) Induction C) Phase I reaction D) Phase II reaction
9. The irreversible lesions that are characteristic of cirrhosis result from deposition of __________ by fibroblasts. A) Epithelial cells B) Lipids C) Bile acids D) Collagen 10. The highest concentration of CYP450 enzyme in the liver are found in: A) Zone 1 B) Zone 2 C) Zone 3 D) Zone 4
11. The reactive intermediate formed when acetaminophen undergoes Phase I metabolism is: A) NAPQI B) Isoniazid C) CYP2E1 D) APAP
12. Vinyl chloride causes a rare form of liver tumor called: A) Cirrhosis B) Hepatocellular carcinoma C) Haemangiosarcoma D) Centrilobular hepatic necrosis
13. The following enzyme is not measured in the serum as an in vivo indicator of liver damage: A) ALT B) NAPQI C) AST D) LDH