BIOL 3451 Lecture Notes - Lecture 18: Neuroblastoma Ras Viral Oncogene Homolog, Sunscreen, Bcl-2-Associated X Protein

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11 Sep 2017

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Chromosomes: multiple copies of mycn are amplified within one large region called the. Heterogenous staining region (green: genome instability driving force for tumorgenesis, genomic instability is minimized by, high-fidelity dna replication in s-phase. Cyclin b levels increase in g2: 2. Cyclin b binds to inactive cdk1: 3. Active cdk1/cyclin b complexes phosphorylate m phase proteins: 4. Cell cycle regulation and cancer: age 1-3, 40% of all cases are familial. In retinoblastoma cells there is no functional rb protein. Thus, e2f activates genes required for g1/s transition; the g1/s checkpoint is overridden and uncontrolled growth and tumor formation occurs: gene mutations and familial breast cancer, brca1 (chromosome 17) Inherited as an autosomal dominant trait: 85% of women with brca1 allele develop a mutation in a second allele and get breast cancer. Increased rate of ovarian cancer: brca2 (chromosome 13) Inherited in an autosomal dominant manner: no increase in ovarian cancer, studies suggest that these genes are involved with dna repair.

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All of the above have equal ability to metastasize

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Cancer of this organ/gland causes the most deaths annually

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The correct order of stages of the cell cycle that a new cell will go through immediately after being produced by mitosis is

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S, G1, G2, M

G1, G2, M, S

G1, S, G2, M

M, G1, S, G2

Question 28

What is the purpose of DNA replication

Question 28 options:

To copy the information in a gene so that extra protein synthesis can be done

To make an RNA copy of the gene

To provide the cell with extra DNA in case the original gets damaged

To ensure that two cells produced by mitosis have the same genetic information as the parent cell

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Which of the following is not a function and/or advantage of mitosis

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It can repair damaged tissue

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It can replace old or damaged cells

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Which stage of the cell cycle occurs just after mitosis

Question 30 options:

Prophase

Save

Question 31 (1.5 points) Question 31 Unsaved

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Prophase

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Which of the following is NOT true of DNA

Question 32 options:

Generally double stranded

Stores the cell genetic information

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Contains A, C, U, and G

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These cell may enter G0 of the cell cycle permanently

Question 33 options:

Hepatocytes

Transformed cells

Neurons

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When a primary spermatocyte, goes through meiosis, how many mature sperm will be produced

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When a primary oocyte goes through meiosis, how many mature eggs will be produced

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BIOL 3451 Lecture Notes - Lecture 18: Neuroblastoma Ras Viral Oncogene Homolog, Sunscreen, Bcl-2-Associated X Protein

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