HHP 3500 Lecture Notes - Lecture 6: Ribosome Biogenesis, Ribonuclease, Ubiquitin

• School: University of Iowa
• Department: Health and Human Physiology
• Course: HHP 3500
• Professor: Peterson Clayton

Document Summary

Initiation factors, ribosomal biogenesis (ribosome concentration), decrease in degradation: read about protein secretion. Proteins act as enzymes, they serve as signaling molecules and receptors, act as transporters, act as motors to move body, and act in immune system; all of these jobs depend on proteins ability to bind to something else. Not bonded by bonding, but forces (due to electrical charges from opposite charges, or hydrophobic forces between non-polar regions) Binding site-location on protein where ligand forces bind to it. Protein may contain multiple binding sites for either the same ligand (like oxygen and hemoglobin), or different ligands. This ligand protein binding, causes a change in function, either activation or inhabitation of protein. Characteristics of the protein binding: chemical specificity-selectively binds to specific ligands. This is based upon complementary shapes: chemical affinity. This is based on shape and charge. High affinity =tight binding: saturation-fraction of total binding sites occupied at any given time.