HHP 3500 Lecture Notes - Lecture 7: Acetyl-Coa, Oxidative Phosphorylation, Mitochondrial Matrix
9 Sep 2016
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Document Summary
Energy from atp hydrolysis is used to power biological work. Atp is synthesized by three distinct but linked pathways. Cells transfer energy from macronutrients to atp: carbs, fats/lipids, proteins. Glycolysis: utilization of glucose as a substrate for atp synthesis, occurs in cytosol of cell, we breakdown one glucose molecule over 10 reactions under enzymatic control, to yield 2, 2-c pyruvate and 2atp, 2nadh, 2h+, Glucose phosphorylated by atp, to produce adp and. Pyruvate turns into acetyl coa, then acetyl coa goes to krebs cycle, then yield goes to etc this gives massive yield: about 34-38 atp: under anaerobic conditions, gets turned to lactate cannot go to krebs. Must modify pyruvate to recycle it, to use again and again in glycolysis. Pyruvate lactate and lactate goes into the blood. Con:only get 2 atp molecule, and causes build up of h+ ions. Pro: this pathway is super fast, so we can build up atp quickly.
