NURS 471 Lecture Notes - Lecture 12: Perfusion, Acidosis, Microorganism
Document Summary
Caused by an untreated infection, progressing to sepsis. Body is unable to contain infection in the original site, causing it to spread via blood. Systemic inflammatory response (sirs) to a documented or suspected infection. Continuum of severity from sepsis to septic shock & mods. Chemicals released into bloodstream to fight infection results in inflammation throughout body: triggers multitude of changes that can damage multiple organ systems that can result in failure. Risk factors: immunocompromised, indwelling/invasive lines, elderly, chronic illnesses, newborns, etoh abuse, malnourished, resistant microorganism, burns. Inflammatory process that occurs with or without an infection. May follow a variety of clinical insults including: infection, pancreatitis, ischemia, multiple trauma, tissue injury, hemorrhagic shock. Body is unable to localize infection and endotoxins released by the invading pathogen and enters. Sepsis the bloodstream- sirs and an infection at the same time. Endotoxins stimulate excessive release of immunomodulators causing an exaggerated response. Pathophysiology: pro-inflammatory mediators released such as cytokines.
