CHEM 451 Lecture Notes - Lecture 5: C-Terminus, Flavodoxin, N-Terminus
Document Summary
Know how alpha helix works in the k+ channel and how selectivity between na+ and k+ works. She will ask use to use examples in the papers to illustrate a point. There"s a typo, oxygen is added with the down arrow, removed with the up arrow!! Paper 2 is long, so we will focus on the first 4 figures. Dipole across peptide bond from charges on n and c -> net positive charge in amino terminus, +ve terminus of helix has ___ and it helps deprotonate s, which is the inactive form of enzyme. Flavodoxin = amino terminus is important to make interactions with the phosphate group in. Alpha helix is a dipole, so fmn can be recognised by flavodoxin (protein) through dipole moment. Selectively allows k to pass through channels, but not na+ even if they look similar, but they have different raii (na+ is smaller than k+ so you might think it"s harder to select for k+)
