CHEM 451 Lecture Notes - Lecture 9: Helix-Turn-Helix, Heptad Repeat, Voltage-Gated Ion Channel
Document Summary
Elix turn helix was in rop protein (protein g -> alpha helical protein) Helix helix interactions in coiled coil, tryptomyosin forms coiled coil on actin. Helix loop helix is unstable by itself, so it needs a metal binding protein or binding ot a partner for stability. Alamethicin - single transmembrane helix - arranged into ligamer in bacteria and forms voltage gated ion channel by ligamerisation. Packing of helices against each other in the bacterial muramidase. Myoglobin fold is seen in lots of other proteins. Look first at 2 helices coiled around each toehr than higher order assemblies. Can have either 2, 3, 4 helices coiled around each other (can be shown in many ways, common in the heptad repeat where the 4th residue is highly conserved (often in leucine) and conservation in position a) Look first at 2 helices coiled around each other, can either have 2, 3, 4 helices coiled around each other.
