CMD 377 Lecture Notes - Lecture 13: Blood Vessel, Autoregulation, Thrombosis
Document Summary
Autoregulation: allows blood vessels to constrict in response to increased blood pressure and relax in response to decreased pressure. Metabolic mechanism: vessels dilate with increased co2 levels and constrict with decreased co2 levels. Perfusion pressure: normal blood pressure in the brain, difference between arterial, intracranial (csf), and venous pressure allows blood to circulate. Hypoperfusion pressure: no pressure difference between the three systems, cause decrease in circulation of blood, distal branches of the three cerebral arteries are affected, water shed lesions occur, causes diffuse sign behaviorally. Ischemic strokes caused by sudden vascular insufficiency: thrombosis. Generally caused by occlusion of blood vessels at the site. Typically caused by atherosclerosis (plaque build up: embolism. The embolus is moved to the distant part of body and gets lodged. Transient ischemic attack (tia: temporary occusion of blood vessel, deficits persist for only a few minutes to hours, followed by complete recovery, often caused by minute emboli which become broken down.
