NUR 234 Lecture Notes - Lecture 2: Spasm, Baroreceptor, Diastole
Document Summary
Sudden pain beneath the sternum, often radiating to left shoulder and arm. Oxygen supply to the heart is insufficient to meet oxygen demand. Two goals of drug therapy: prevent mi and death, prevent myocardial ischemia and anginal pain. Determines of cardiac oxygen demand and supply: oxygen demand. Chronic stable angina (exertional angina: pathophysiology. Triggered by an increase in physical activity. Emotional excitement, large meals, and cold exposure may also trigger. Underlying cause: coronary artery disease- characterized by deposition of fatty plaque in the arterial wall. If partially blocked, angina will occur; if fully blocked, mi will occur. Anginal pain results from imbalance between oxygen supply and oxygen demand: treatment strategy. Goal is to reduce the intensity and frequency of anginal attacks. Done by drugs that decrease heart rate, contractility: overview of therapeutic agents afterload and preload. Organic nitrates, beta blockers, calcium channel blockers, and. Ranolazine can be combined with the first 3 for additional benefits.
