BME 410 Lecture Notes - Lecture 18: Angiogenesis, Electric Potential, Agarose
20 Apr 2016
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Variables: mass transport: 100 m oxygen diffusion limit, fabrication technology, imaging, properties are interdependent, composition (biomaterial, material properties (stiffness, conductivity, etc. , geometry (porosity, anisotropy, topography, etc. , degradability (cid:2) (cid:2) Conventional techniques: particle leaching, gas foaming, etc. Biodegradable polymers (pla, pcl, etc. ) dissolved in volatile solvent: hexafluoroacetone (hfip) Lecture 18: tissue engineering: scaffolds, fibers, and 3d printing. Steps: polymer is dissolved in solvent poured into mold with porogen solvent is evaporated porogen is dissolved porous structure is obtained. Angiogenesis: new blood vessels are formed in porous scaffold from angiogenic growth factors. Bone and cartilage regeneration: chondrocytes or osteoblasts placed into porous scaffold to create cartilage and bone. Gasfoaming: form gas bubbles inside polymer solutions pores. Freezedrying: polymer solutions cooled until solvent forms ice crystals pores. High voltages applied to polymer solution inside syringe. Extrudes polymer nanofibers with centrifugal forces (cid:2) (cid:2) (cid:2: hydrostatic + centrifugal pressures must exceed capillary force. Higher rotation speed means smaller fiber diameter.
