BIO 346 Lecture Notes - Lecture 4: Rheumatoid Arthritis, Whitehall Study, Wealth Inequality In The United States
Document Summary
3d conformation of chromatin - look at frequency of interaction between pieces of dna. Hi-c - tool used to see this. Cross link dna (expose to fixative - make covalent bond between protein) Cut with restriction enzyme sticky ends ligate. Barker hypothesis (developmental origins of adult diseases)- wide variety of diseases. Heart attack, stroke, diabetes, obesity - all stress linked. Tended to link to stuff that happened earlier in life. Childhood ses, birthweight, height, breast feeding, sibling helath , Height used as proxy for nutrition and wealth of a society. Make references of time and space to see how healthy people were. Our generation is a little bit taller than our parents. Ses - grouped descriptions: income, living conditions, education and perceived social status. Makers for something we want to describe use as measure. Ses strong predictor of health and emotional well being (at intermediate levels as well)
