BIO 365S Lecture Notes - Lecture 27: Podocyte, Basal Lamina, Blood Vessel
Filtration
Def’: oeet of plasa ate ad solute fo gloeulus ito Boa’s apsule
Non-Selective!
A lot of lood oes to this aea, do’t hae tie to select actively. Can only create a sleet to
select against molecules that are too big. Figure it out later to put what molecule back.
Molecules in the plasma that are filtered into the nephron: water, glucose (normally not in
uie eause that’s diaetes, but WILL be filtered into the nephron and body figures a way to
bring it back), Na+.
RBC CAN’T e filteed ito the epho.
The epithelium around glomerular capillaries
is modified into podocytes.
Capillary = very leaky area.
Outside, puts podocyte cell (main one to create sleeve), but has 3 layers.
Podocyte foot processes surround each capillary, leaving slits
through which filtration takes place. Mesangial cells between
the capillaries contract to alter blood flow.
The glomerular capillary endothelium, basal lamina,
ad Bowa’s capsule epitheliu create a three-
layer filtration barrier. Filtered substances pass
through endothelial pores and filtration slits.
Sleeve made of 3 layers: 1st = capillary (blood vessel), 2nd = negative charge to push back most
proteins, 3rd = podocyte (very limited function, physically stays there).
Filtration Slits
• Capillary Endothelium
• Basement Membrane
• Boa’s Capsule
Epithelium (podocytes)
Podocytes = work like poles, physically decide sleeve type.
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Because of this simple process, decides filtration rate. How much volume can be handled per
day/min.
GFR = 180L/day.
If important molecules like glucose goes through the tube, body will expend energy to take it
back.
Driving force of Filtration
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Def"(cid:374): (cid:373)o(cid:448)e(cid:373)e(cid:374)t of plas(cid:373)a (cid:449)ate(cid:396) a(cid:374)d solute f(cid:396)o(cid:373) glo(cid:373)e(cid:396)ulus i(cid:374)to bo(cid:449)(cid:373)a(cid:374)"s (cid:272)apsule. A lot of (cid:271)lood (cid:272)o(cid:373)es to this a(cid:396)ea, do(cid:374)"t ha(cid:448)e ti(cid:373)e to select actively. Can only create a sleet to select against molecules that are too big. Figure it out later to put what molecule back. Molecules in the plasma that are filtered into the nephron: water, glucose (normally not in u(cid:396)i(cid:374)e (cid:271)e(cid:272)ause that"s dia(cid:271)etes, but will be filtered into the nephron and body figures a way to bring it back), na+. The epithelium around glomerular capillaries is modified into podocytes. Outside, puts podocyte cell (main one to create sleeve), but has 3 layers. Podocyte foot processes surround each capillary, leaving slits through which filtration takes place. Mesangial cells between the capillaries contract to alter blood flow. The glomerular capillary endothelium, basal lamina, a(cid:374)d bow(cid:373)a(cid:374)"s capsule epitheliu(cid:373) create a three- layer filtration barrier. Filtered substances pass through endothelial pores and filtration slits.
