BIO 370 Lecture Notes - Lecture 21: Linkage Disequilibrium, Allele, Genetic Hitchhiking
Recombination Dissipates Linkage Disequilibrium
The foregoing is of more interest than simply
making a list of things that can create or
maintain linkage equilibrium in the LACK of
actual physical linkage.
We are about to see that these phenomena
are necessary to maintain linkage disequilibrium
EVEN WHEN LOCI ARE PHYSICALLY LINKED!
In the absence of other evolutionary processes, linkage disequilibrium is broken down by the
process of recombination, and eventually it disappears.
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This illustrates a Hardy-Weinberg population at linkage equilibrium, as indicted by the equal
proportions of the gold coupling regions and the green repulsion regions.
When the coupling regions are larger than the repulsion regions, the coefficient of linkage
disequilibrium is positive.
When the repulsion regions are larger than the coupling regions, the coefficient of linkage
disequilibrium is negative.
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
The foregoing is of more interest than simply making a list of things that can create or maintain linkage equilibrium in the lack of actual physical linkage. We are about to see that these phenomena are necessary to maintain linkage disequilibrium. In the absence of other evolutionary processes, linkage disequilibrium is broken down by the process of recombination, and eventually it disappears. This illustrates a hardy-weinberg population at linkage equilibrium, as indicted by the equal proportions of the gold coupling regions and the green repulsion regions. When the coupling regions are larger than the repulsion regions, the coefficient of linkage disequilibrium is positive. When the repulsion regions are larger than the coupling regions, the coefficient of linkage disequilibrium is negative. Suppose some of the haplotype pairs undergo recombination between the a and b loci. As shown previously, recombination events generate new haplotypes only when there is recombination in double heterozygotes.
