CH 110K Lecture Notes - Lecture 10: Methyl Benzoate, Peptide Synthesis, Protonation
Document Summary
We can"t heat the reaction we must: change it to r-o (oxides, powerful nu and base! So we"ll get an alcohol: acyl halides, problems: not very long shelf life, you have to buy them right before the reaction, so we won"t do it! Not particularly safe: you don"t need it, you can fischer, reaction under acidic reactions, you can make an ester, emil fischer, big name in orgo. Adolf synthesized indigo (that"s who he got his phd from) Married when he was 36, his wife passed away 7 years later, first son died in wwi, second committed suicide, third son was faculty at uc berkeley. Was awarded nobel prize in 1902, then he committed suicide in 1919. Comes from original paper published in blank with. It needs to be a strong acid (usually conc. sulfuric acid) You need to protonate a double bonded oxygen that isn"t a good base really.
