BIO-183 Lecture Notes - Lecture 13: B-Cell Receptor, Major Histocompatibility Complex, Anaphylaxis
Document Summary
Antigen- immunogen- foreign molecules that, highly individual and stimulate a response by specific b and t cells: two traits: Memory: immune, t and b cells produce memory cells which will now be programed for future attack if same antigen. Summary of contrasting properties of b and t lymphocytes: B cells develop in bone marrow and t cells develop in the thymus, both. Ultimately migrate to the lymph nodes where further develop= lymphocytes . Specific surface markers: immunoglobulin- b, t cell receptor and cd molecules- t. Immunoglobulin- large glycoprotein molecules that serve as the antigen receptors of b cells, when secreted are antibodies, have flexible antigen binding sites and versatile variable regions. Cd 4- t helper cells- that ask for help - activates and regulates cell mediated immunity pathway to antigens, drives b cell proliferation and t cells. Cd8- killer t cells (cytotoxic)- destroy virally infected cells/foreign cells within the body by lysis, requires mhc-i for function.
