BCMB 230 Lecture Notes - Lecture 5: Lipid Bilayer, Phospholipid, Epithelium
7 Sep 2016
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General rule: proteins are water soluble, but may have portions that are lipid soluble. Portions in the membrane should be lipid soluble. This does not make the molecule amphipathic because the charge is not all at one end. Post-translational modifications: primarily change the activity of the protein. H bonding and ionic bonding: might be a hormone, or by-product of metabolism. Generally, phosphorylated proteins are the active form of the protein. Adding a phosphate group requires a lot of energy. Splitting may occur inside the cell or even outside of the cell in a different organ. Polypeptide could have been made active or inactive, and splitting changes the active state. If you splice out the wrong sections of the protein mrna script you have to start over from scratch. Other methods include: glycosalation: binding of a sugar or oligosaccharide, methylation: binding of methyl groups. Can help get the proteins to the right place or activate the protein.
