BCMB 401 Lecture Notes - Lecture 1: Tris, Hydrophile, Acid Dissociation Constant

• School: UTK
• Department: Biochemistry and Cellular and Molecular Biology
• Course: BCMB 401
• Professor: Koontz

Document Summary

G= h-t s: negative to be spontaneous, h= enthalpy (charge-charge interactions, s= entropy (hydrophobic interactions) Electrostatic salt bridge : whole charge, whole charge interactions, strongest of the non-covalent interactions, longest range of interactions. Hydrogen bonding: partial charge, partial charge (charge distribution, there is a donor and an acceptor. Van der waals: partial charge, partial charge, weaker than hydrogen bonding, result from redistribution of electrons, can occur between nonpolar atoms, partial charges from the movement of electrons attracting each other, can only come 1. 7 angstroms close. Dielectric constant: water: 80 (polar, hexane 1. 89(nonpolar) Competes for the charge between the two molecules: hexane: no competition molecule dissolves. Hydrophobic effect- water is highly polar and prefers to interact with water. Non-polar molecules in polar solvent clump together: this clumping is driven by entropy + s water molecules break away leading to. Micelle- circular structure with a hydrophobic core and hydrophilic heads. [h+] determines ph: strong acids and strong bases dissociate completely, weak acids/bases.