BIOL 2100 Lecture Notes - Lecture 38: Blotting Paper, Iron Response Element, Intron
19 Nov 2016
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Gene location differs in each cell, can be on naked or intact chromatin. Beta globin may not be expressed because in intact dna. The same region in each cell may differ in that they may be closed. Cpg methylation specifically cytosine has a methyl group added to it. C and g adjacent on same strand. Alters chromatin so that it makes promoter inaccessible, inhibiting the rna polymerase and transcription. 5" cpg 3" (cid:454) 5" cpg 3" (cid:455) On this dna x is not expressed. After synthesis (semiconservative) after replication double helix consists of one methylated and one non-methylated strand. After going through multiple rounds of replication, some might be methylated and some wont. Enzymes that methylate cpg, methylate the opposite strand. Because of this, methylation pattern is sustained, example of epigenetic modification. Epigenetic modification changing gene expression that can be maintained through cell division. Gene imprinting epigenetic silencing of genes (autosomal) and occurs differently in males vs. females.
