BIOL 2100 Lecture Notes - Lecture 5: Peptide, Hydrogen Bond

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Protein Structure
Secondary structure: (helix and sheets) are different but very similar because they both
contain hydrogen bonding and because they are on the backbone
they don’t contain a side chain
o what determines a sheet or a helix?
Based on folding and the structure it needs to fix
Tertiary structure: overall structure of the polypeptide chain
o Many proteins can be associated with non-proteins
Components like nucleotides can be attached to a protein
Quaternary structure: interactions between multi-polypeptide chains
o Disulfide chain: helps stabilize overall structure of proteins and keep them
together
o Some contain carbohydrates (glycoproteins), and have the sugars added
They have distinct functional and structural domains
Protein chaperones do not dictate shape of another protein, but protects them and
allows them to find their right structure (brought by increased temperature)
o They can protect a protein from denaturing
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