NSCI 270 Lecture Notes - Lecture 2: Etiology, Summary Offence, Spasticity
22 Jan 2018
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Some can be assessed for diagnostic or risk indication purposes: structural abnormalities. Injury/inflammation/tumor/gross structure changes: molecule levels in blood or spinal fluid, ex. Some are only observed post-mortem or in experimental models: structural abnormalities not tested in life, ex. No reason to scan scz patients: histological diagnosis, ex. Plaques and tangles for azd: molecule levels in brain tissue, ex. gene expression signatures in suicide victims, ex. Others are only known in research settings at this time: ex. Significant brain differences in prenatal brain scans in siblings of asd. The physical basis of the disease is referred to as the lesion. Destructive or deficiency phenomena: associated with destruction of nervous tissue, ex. Infraction, tumor, trauma: process that depress or block nerve function, ex. Seizures and pins-and-needles or burning paresthesia"s or peripheral neuropathy: excessive neuronal firing secondary to pathological depolarization. Release phenomena: unmasking by destruction of an inhibitory influence, ex.
