1. How do viral proteins get localized to the nucleus?
2. How do viral proteins get localized to the plasma membrane?
3. How does a nascent protein get targeted to the ER?
4. What amino acid residue on a target protein is attached to the sugar?
5.Where in the cell are N-linked oligosaccharides FIRST added to a glycoprotein?
6.Where in the cell does the initial sugar get processed into its mature form?
7. That is, which exact compartment(s) of the secretory pathway is mannose removed? Galactose added? Sialic acid added? How does the position of glycosylation (N-linked vs internal) affect which chaperone is used to properly fold proteins in the ER?
8. What compartments comprise the secretory pathway in mammalian cells?
9.How do proteins get transported from the ER to the Golgi?
10.How do the transport vesicles return from the Golgi to the ER?
11.What happens to their components when they get there? How does poliovirus inhibit the secretory pathway?
SHORT answers please