GENETICS 677 Lecture Notes - Lecture 2: Tumor Suppressor Gene, Chronic Myelogenous Leukemia, Theodor Boveri
Document Summary
Genetics 677 lecture 2 september 15, 2016. Key facts: will affect 40% of americans and is the 2nd leading cause of death in americans, cancer incidence is age-related, but can occur at any age in hundreds of different tissues. Drugs targeting cancer are very profitable right now, meaning pharmaceutical companies can charge exorbitant rates for treatment. Early milestones in cancer research: observation that cancer cells have abnormal chromosomes such as aneuploidy (hanseman, 1890s), theodor boveri proposes that cancers arise from single cells (early. 1900s: first chromosomal translocation characterized, philadelphia chromosome, nowell and. Hungerford in 1960, in chronic myelogenous leukemia (cml) 95% of cml patients have the translocation of 9q34. 12 abl from chromosome. Occurs due to a fusion between bcr1 and c-abi genes, which results in the. Discovery of oncogenes: in 1910, francis rous first inferred the existence of specific genes associated with cancer cells after studying sarcomas in chickens.
