BSCI-1510 Lecture Notes - Lecture 18: Aurora B Kinase, African Clawed Frog, Condensin
9 May 2016
School
Department
Course
Professor
Document Summary
P34 is a cdk and p45 is a cyclin: demonstrated that cell cycle required protein synthesis but not rna synthesis or nucleus, 581-602. Mitosis process of nuclear division where he replicated dna molecules of each chromosome are faithfully segregated into two nuclei. Prophase: duplicated chromosomes are prepared for segregation and the mitotic machinery is assembled. Chromosome compaction/condensation occurs to make them shorter by adding condensin, doesn"t change nature just packaging. Condensin, along with atp and topoisomerase, induce positive supercoiling. Condensin is phosphorylated by cyclin-cdk from g2 to mitosis. Chromatids, held together by cohesin until they are separated. The cohesin can dissociate as it becomes compacted by polo-like kinase and aurora b kinase, the are are looser but still tight at centromeres. Mitotic spindle formation: first microtubules appear in an aster formation around each centrosome. Centrosomes separate and move to opposite ends of the cell, the microtubules between them stretch and elongate. Nuclear envelope is broken down by specific cdks.
