BIOL 2604 Lecture Notes - Lecture 5: Prentice Hall, Semiconservative Replication, Chicken Anaemia Virus
Document Summary
Trimethropim and sulfonamides mes with paba-dhf-thf folid acid synthesis chain. 50s and 30s protein synthesis inhibitors, streptomyocin attacking 30s is an example, mess with ribosomes. Target modification, ex: rifampicin) mess with beta subunit of rna polymerase so target does not mess up. Ex: efflux out tetracycline in enteric bacteria (bacteria in the body) Antibiotic modification modify the antibiotic, like b-lactamase (penicillinase). Ex: chloramphenicol actyltrasnferase move the acetyl group. Circumvention of folic acid synthesis (sulfonamides), use something other than folic acid synthesis or just pull that shit right out of the environment without making it. Antibiotic impermeability block antibiotic from coming in. Ex: penicillin in pseudomonas aeruginosa antibiotic can"t get in. Viruses are genetic elements with obligate intracellular replication cycle. Virions are the extracellular form which include nucleic acid and normally protein coat with maybe envelope. Viruses classified by host they inflict or by the type of genetic material they contain.
