BIOL 2604 Lecture 4: Lecture 4 Notes Metabolism
Document Summary
Enzyme catalytic cycle: substrate is bound to enzyme active site, enzyme-substrate complex forms, strain is placed on bond, products are released, enzyme is ready to begin new catalytic cycle. Catalysis and enzymes: enzymes, frequently have the suffix -ase , have an active site , may undergo a conformational change during catalysis. Nad+ reduction steps: enzyme i reactions with e- donor and oxidized form of coenzyme, nad, nadh and reaction product are formed, enzyme ii reacts with e- acceptor and reduced form of coenzyme, nadh, nad+ is released. Two ways to make atp: substrate-level phosphorylation, transfer of phosphate from organic intermediate (often pep) to adp to make atp, oxidative phosphorylation, directly attach pi to adp to form atp. Fermentation: recycles reduced coenzymes, requires no etc, produces useful economic products, this is what organisms must do if they do not have a good terminal electron acceptor (like o2).
