HNFE 3025 Lecture Notes - Lecture 3: Glutathione Reductase, Beta Cell, Glut4
16 Jul 2016
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Hexose absorption- 6 carbon sugar (fructose, sucrose, galactose); sglt1(brings glucose into the cell and relies on sodium potassium pump) Glut2- km is high, lots of buildup due to low affinity. Km- cxn of substrate that gives half the maximal velocity. Glut 1- every cell, steady influx of glucose. Glut 3- the brain, low km bc its still functioning. Glut 4- insulin sensitive transporter, translocate in response to insulin, below homeostatic levels, sensitive to exercise. Glut 2- pancreatic beta cell, if km is 5 or 6, its gonna overproduce insulin, tell your body to store everything. Glut 2 and glut 4 are most important. Phosphoglucomutase- converts g6p g1p or vice versa, needed for glycogen storage or glycogen breakdown, excess g6p when storing. Malic enzyme- important for cells that don"t have glutathione to increase nadph. Hexokinase is found everywhere, glucokinase is found in the liver. Glucokinase is reversible while hexokinase is not, glucokinase can remove phosphate.
