PSY 320 Lecture Notes - Lecture 11: Striatum, Circulatory System, Nmda Receptor Antagonist
Document Summary
In drugs there as a conditioned stimulus that causes drug seeking behavior. Consolidation getting memory from short term to long term memory. Inactive memory to reactivation- to active memory to reconsolidation to inactive memory again. These processes were blocked in this experiment. Reconsolidation requires putting memory back into stable state again. Previous literature says yes, and that glutamate and nmda/ nmdar is involved. This is involved in drug, food, water. Put catheter right through jugular for one and one in amygdala. Memory re-activation happened after self administered cocaine. Some of the got the injections before activation and some got after. Did not work well when given systemically . Experiment b is to analyze expression of ziff268. 1 drug went into brain, one went into systemic circuit. Stimuli paired with drug taking (tone and light) Learning to associate those cues with drugs. At some point connection would become ltm.
