PSY 320 Lecture Notes - Lecture 18: In Situ Hybridization, Glutamate Decarboxylase, Superior Frontal Gyrus
Document Summary
Final journal article: the title of this article is titled gene expression deficits in a subclass of gaba. Alterations in the circuitry of the prefrontal cortex may contribute to the impairments of certain cognitive functions like working memory. Circuit neurons (play role in regulating pfc information processing during working memory tasks) exhibit altered gaba neurotransmitters in the fc of subjects with schizophrenia. Gad 67 and gat-1 reported to be below the limit of detection in pfc of patients with schizophrenia. Most cortical gaba neurons express one of three calcium binding proteins- pv, cr or d-28. These markers have been used to id specific morphological and functional subgroups of gaba neurons. Pfc gaba neurons, altered transmission more prominent in pv rather than ct containing neurons in subjects with schizophrenia. Hypothesized that selective involvement of pv containing neurons in the pathphysiology of schizophrenia results in altered levels of pv but not cr, mrna expression in the pfc of subjects with schizophrenia,
