L41 BIOL 2970 Lecture Notes - Lecture 36: Coronary Artery Disease, Mayo Clinic, Cholesterol

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Mayo clinic study -- post-mortem data on odds of coronary artery disease. C-h = high cholesterol, c-m = medium cholesterol, c-l = low cholesterol. Allele 3 is most common in the population. The results of looking at both the environmental and the measured genotypes and how they interact can give more useful information on risk for a disease than measuring either of the two alone. Population-genetic measure of evolution -- change in allelic frequency in the gene pool. Evolutionary forces in populations -- factors or processes that can change the frequency of an allele in the gene pool a. Mutation: causes many small changes -- critical for introducing new alleles into a population. N = number of individuals in the population. Genetic drift: finite population size causes evolutionary change (sampling error -- random change) Property 1: no direction -- equally likely to increase or decrease the frequency.

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