L41 BIOL 2970 Lecture Notes - Lecture 31: Hemoglobin, Electrophoresis, Scurvy
25 Feb 2016
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Phenotype any measurable trait, either discrete or coninuous. Coronary artery disease (western socieies) a type of phenotype. Heritability of 65% [correlaion between (parent, ofspring) = 0. 325] because of high heritability, the disease is believed to have a geneic component. 46% of all geneic disease consist of cad. No discrete phenotypic categories (mild symptoms to lethal) No single factor, either geneic or environmental, that is either necessary or suicient for. Major features of most geneic traits: complexity of genotype/phenotype relaionship represents interacions among muliple geneic and environmental factors, confoundment of frequency and apparent causaion in complex systems requires study at the level of populaions (staisical) No single factor a1 an is both necessary and suicient for b. Many factors are neither necessary nor suicient for b. Mutaion in the 6th amino acid sequence valine replaces glutamic acid at this posiion. Electrophoreic mobility of hemoglobin codominant (heterozygous for both alleles a and s) Viability overdominant heterozygous genotype has the highest value.
