E62 BME 140 Lecture Notes - Lecture 10: Olfactory Bulb, Bipolar Neuron, Spacetime
6 Nov 2015
School
Department
Course
Professor
Document Summary
In humans, odors are detected by neurons lining the nasal cavity, and processed in the olfactory bulb. Olfactory receptor neurons are a type of bipolar neuron. Each olfactory receptor neurons is only linked to 1 gene and is only sensitive to certain ligands. Each chemical will activate some combinations of the genes. Odor receptor neurons (orns) exhibit temporally diverse firing patterns to a given odor. The pn patterns are reliable and are odor specific. Pn ensemble activity trace concentration-specific trajectories on odor-specific manifolds. Use odor trajectories to compare relationship between odor trajectories and concentration of odors. The greater the concentration, the larger the trajectory, and the greater the intensity of the odor. On-transient: vigorous activity for up to 1-1. 5 s after odor onset. Steady-state: convergence to stable firing regime until odor pulse is terminated. Off-transient: vigorous activity for a few seconds after odor onset.
