E62 BME 140 Lecture Notes - Lecture 12: Acoustic Wave Equation, Medical Ultrasound, Therapeutic Ultrasound
28 Dec 2015
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Document Summary
Ultrasound: mechanical waves with frequencies higher than 20 khz. Development of the acoustic wave equation can proceed from three basic equations: Wavelength = propagation speed/frequency c = 1540 m/s (average speed of sound in tissue) Focused ultrasound (fus): concentrates ultrasound energy with high precision onto a target deep in the body. No radiation, deep penetration (noninvasive), focused, low cost. Hifu mild hyperthermia triggered drug delivery (controls drug delivery for extended period of time. ) Hifu thermal ablation: obliterates tumor without surgery by using focused mechanical waves. Large range of applications for use in multiple types of tumors and cancers. Mri-guided hifu for thermodox delivery: non-invasive localized and controlled. Drug is injected into the body and the drug is released by the thermodox when appropriate temperature reached. Mri is used to monitor to temperature, so the appropriate temperature is achieved for the drug to release. Imaging: contrast enhanced ultrasound imaging echocardiography, heart, liver, breast, kidney, etc.
