L07 Chem 481 Lecture Notes - Lecture 27: Rheumatoid Arthritis, Pharmaceutical Industry, Immunoglobulin Light Chain
13 Dec 2016
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Document Summary
Cytosine methylation is common to all large-genome eukaryotes but is present in only some small-genome eukaryotes. Cytosine methylation is mediated by a conserved group of proteins called dna (cytosine-5) methyltransferases (dnmts: the biological functions of cytosine methylation are fundamentally different in prokaryotes and eukaryotes. Dna methylation has a central role in host restriction/destruction of phage dna in bacteria, but there is no evidence that euks restrict viruses in this way. Usually there are several m5cpg to recognize, if not in one place then another. Accessibility can play a factor: mechanism of dna-methylation mediated repression, preventing activation: dna methylation in the cognate dna-binding sequences of some. Tf can result in inhibition of dna binding. Addition of methyl groups to dna is coupled with transcriptional repression and chromatin modification: post tss mbp blockage of transcription: dna methylation within the body of genes can also have a dampening effect on transcriptional elongation.
