L07 Chem 481 Lecture 19: Lecture 19
10 Mar 2017
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Glucokinase is half saturated at 10 mm (glucose in blood is ~4-5 mm) Liver is not very sensitive to glucose increase. Liver is used as a buffer to regulate blood glucose levels. If not enough glucose, liver will not use glycolysis to get energy, will use other pathways and leave glucose for the other tissues. When glucose levels are high, the liver will use the glucose to generate energy because glucokinase activity will increase. In other cells that don t have glucokinase, they will utilize glucose as soon as there is any glucose because it will do glycolysis. Other hexokinases have an extremely high affinity for glucose, much higher than glucokinase. A regulator protein binds to glucokinase and pull it into the nucleus to inactivate it. Large amounts of fructose 6-phosphate will encourage the regulator protein to bind to glucokinase. Glucose encourages glucokinase being pulling out of the nucleus (discourages the regulator protein from binding)
