NURS 364 Lecture Notes - Lecture 12: Single-Nucleotide Polymorphism, Nonsense Mutation, Silent Mutation
14 Dec 2017
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Document Summary
They are the carriers of the gene or unit of heredity (dna). Chromosomes are composed of two longitudinal sister chromatids. Untwisting and unzipping of the weak hydrogen bond between dna bases leaving a single strand with each base unpaired. Enzyme that travels along the single dna strand creating the new complementary dna base pair. The central dogma of molecular biology states that information flows in one direction: Despite wide range of manifestations, there are common mechanisms for genetic disorders: mechanism of mutation. Inheritance of an altered gamete cell: mutation of gametic cells during meiosis (new mutation), mutation during early embryogenesis, mutations at the base pair/ nucleotide level, mechanisms of genetic disorder, mechanism of mutation occurring during dna replication. Base pair substitution - substitute one base nucleotide for another. 10-30 million snps in the human genome: mechanisms of genetic disorder, mechanism of mutation occurring during dna replication.
