PHARMACOLOGY Lecture Notes - Lecture 1: Pethidine, Nephrotoxicity, Hepatotoxicity

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Expected response of medication, therapeutic goal is achieved. Because a medication may in uence many body systems at the same time. Nausea (maybe stopped if dose is reduced) Imply more severe symptoms or problems that develop because of the drug. Damage to kidney (nephrotoxic) or liver (hepatotoxic), bleeding medication must be stopped. Idiosyncratic responses unexpected drug reaction (strange, peculiar) May be the result of missing or defective metabolic enzymes caused by a genetic or hormonal variation of the individual. Patient"s reaction may be just the opposite of expected side e ect. Decongestant (pseudoephedrine hydrochloride) sedation or drowsiness (expected) Paradoxical response: insomnia and tachycardia or rapid heartbeat, overly stimulated. Allergy - a sensitivity caused by antibody response to a drug. Individual takes the drug body developed antibodies into it takes the drug again. Ag-ab reaction produces hives, rash, itching, swelling of the ski. Mild allergic reaction ( rst administration) more severe anaphylactic reaction (2nd administration) true medical emergency.

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