HMM104 Study Guide - Final Guide: Deakin University, Hematology, Growth Factor
Document Summary
Immunology & haematology hmm104 deakin university. Vascular wall endothelium: lines entire circulatory system (1013 cells in a single layer) Activate clotting (von willebrand factor (vwf) & tissue factor (tf)) Platelets: small cell fragments (between 140,000 - 400,000/ul of blood) with a 7 10-day life cycle. Contains mitochondria, glycogen (energy), granules (for clotting) & membrane glycoproteins (gpib & iib/iiia for adhesion & aggregation) At rest they act as smooth non-sticky discs. When stimulated, they become sticky spheres that aggregate & stick to injured surfaces & release chemical messengers. -granules: fibrinogen (forms clot), platelet factor 4 (antagonises heparin, an anti-coagulant), platelet derived growth factor (growth factor) & -thromboglobulin (chemokine) Dense ( ) granules: adp & calcium (used in aggregation & vasoconstriction) Produced from megakaryocytes (large cells with lobed nucleus & polyploid with up to 32 copies of normal dna) which themselves are produced from mep (megakaryocyte erythroid progenitors) via thrombopoiesis (tpo) Mature megakaryocytes form long processes which break into 1000"s of platelets.
